Furan, 2-(1,7-nonadiene-3,5-diynyl)-, (E,E)-
Atractylodin
CAS: 55290-63-6
Molecular Formula: C13H10O
Furan, 2-(1,7-nonadiene-3,5-diynyl)-, (E,E)- - Names and Identifiers
| Name | Atractylodin |
| Synonyms | Atractydin Atractylodin ATRACTYLODIN Atisine chloride Atractydin (E,E)-2-(1,7-Nonadiene-3,5-diynyl)furan (e,e)-2-(1,7-nonadiene-3,5-diynyl)furan 2-[(1E,7E)-1,7-Nonadiene-3,5-diynyl]furan (1E,7E)-1-(2-Furyl)-1,7-nonadiene-3,5-diyne Furan, 2-(1,7-nonadiene-3,5-diynyl)-, (E,E)- Furan,2-(1E,7E)-1,7-nonadiene-3,5-diyn-1-yl- 2-[(1E,7E)-nona-1,7-diene-3,5-diyn-1-yl]furan |
| CAS | 55290-63-6 |
| InChI | InChI=1/C13H10O/c1-2-3-4-5-6-7-8-10-13-11-9-12-14-13/h2-3,8-12H,1H3/b3-2+,10-8+ |
Furan, 2-(1,7-nonadiene-3,5-diynyl)-, (E,E)- - Physico-chemical Properties
| Molecular Formula | C13H10O |
| Molar Mass | 182.22 |
| Density | 1.056±0.06 g/cm3(Predicted) |
| Melting Point | 52 °C |
| Boling Point | 305.5±34.0 °C(Predicted) |
| Flash Point | 142.6°C |
| Solubility | DMSO : ≥ 6 mg/mL (32.93 mM);H2O : < 0.1 mg/mL (insoluble) |
| Vapor Presure | 0.00148mmHg at 25°C |
| Appearance | Colorless needle crystal |
| Storage Condition | 2-8°C |
| Refractive Index | 1.591 |
| MDL | MFCD01075143 |
| Physical and Chemical Properties | Derived from lancea (Thunb.) DC, Atractylodes of Atractylodes, Atractylodes of Compositae. |
Furan, 2-(1,7-nonadiene-3,5-diynyl)-, (E,E)- - Reference
| Reference Show more | 1. Xiao Chunping, Xia Yan, Zhang Qiang. Quality Evaluation of Atractylodes lancea from different habitats in Jilin province [J]. Journal of Changchun University of Traditional Chinese Medicine 2018 v.34(05):62-65. 2. Bi Jiamu, Yin Haobo, Deng Cong, etc. Comparative analysis of content of atractylodis and chlorophyll in three species of Atractylodes lancea from Liaoning [J]. Guangdong chemical industry, 2019, 046(009):45-47,69. 3. Sun jinweng Lili, Xiao Chunping, etc. Quality Analysis of Atractylodes lancea medicinal materials with different growth years by HPLC-one-Test multi-evaluation method combined with color difference principle [J]. China pharmacy 2020 v.31;No.677(11):39-44. 4. Li Qiang, Yao Xia, Sun Kai et al. Effects of different light quality on growth, antioxidant enzyme activity and volatile oil content of Atractylodes lancea [J]. Chinese Journal of Experimental prescriptions 2018(10):27-32. 5. Deng Cong, Yin Haobo, Wang Na, etc. Comparison of volatile components in atractylodes plants from Liaoning [J]. Liaoning Journal of Traditional Chinese Medicine, 2020, v.47;No.516(05):162-165. 6. Lu Qijie, nest Jianguo, Gu Wei, etc. Effects of copper stress on the accumulation of three medicinal components and the expression of two key enzymes in the biosynthesis of Atractylodes lancea [J]. Chinese herbal medicine, 2019, 50(03):173-178. 7. Li Qinyu, Wu Weigang, Cui Bo, et al. Quality evaluation of Atractylodes lancea by high performance liquid chromatography combined with multivariate statistical analysis [J]. Journal of Pharmaceutical Analysis, 2018, v.38(04):56-66. 8. Yuan Miao, Cai Xiaoxia, Zhang Peng, Jiang Cuiping, Tao Ye Qin, Xiong Dan, Xie Zongming, Qiu Xiaonian. Study on the quality standard of chenginverse shrinkage spleen granules [J]. China modern distance education of traditional Chinese medicine, 2021,19(05):136-139. 9. [IF = 5.81] Xiao Xiaofei et al."The Anti-Diaria Activity of the Non-toxic Dihuang Powder in Mice." Front Pharmacol. 2018 Sep;0:1037 10. [IF = 4.215] Zhang Aqin et al."Effect of droght on photosynthesis, total antioxidant capacity, bioactive component accumulation, and the transscript of Atractylodes Lancet. Bmc Plant Biol. 2021 Dec;21(1):1-14 |
Furan, 2-(1,7-nonadiene-3,5-diynyl)-, (E,E)- - Reference Information
| Atractylodes lancea active ingredient | atractylodin is a substance extracted from the dried rhizome of The Compositae plant Atractylodes lancea or Atractylodes lancea. Volatile oil is the main active ingredient in Atractylodes lancea, the highest content of Atractylodes macrocephala, Atractylodes macrocephala has hypoglycemic, diuretic, promoting gastric emptying, anti-inflammatory, anti-tumor and other pharmacological activities. This information was compiled by Shi Yan. |
| physical properties | colorless needle crystals. The melting point was 50.5-53 °c. |
| source plant | the main source is the dried rhizomes of Atractylodes lancea or Atractylodes lancea. [Place of origin] Southern Atractylodes lancea is mainly produced in Jurong, Zhenjiang and Lishui of Jiangsu, Xiangyang and nancamphor of Hubei, Tongbai and Tanghe of Henan, and also produced in Zhejiang, Anhui and Jiangxi. To Tongbai, Anhui, Anhui, Jiangsu province, the best quality, known as "Atractylodes lancea", regarded as authentic herbs. Atractylodes lancea produced in Northeast China is called "Atractylodes lancea". Hebei, Shanxi, Shaanxi and other places produced by the Atractylodes lancea "north". [plant morphology] Atractylodes lancea: perennial herb, up to 80cm. Leaves alternate, leathery; Upper leaves generally not split, sessile, ovoid to elliptic, margin spiny-serrate; Lower leaves elliptic. Capitulum terminal, involucre cylindrical, flowers tubular flowers, white or pale purple. Achenes have feathery crown hairs. Rhizomes were irregular nodular cylindrical, slightly curved. The surface is gray-brown, with wrinkles and residual fibrous roots, with stem marks and residue base at the top. Firm in quality, with yellow-white or gray-white cross section, with most orange-yellow or brown-red oil spots scattered, commonly referred to as "Cinnabar spots". Figure 1 shows Atractylodes lancea |
| identification | trait identification 1. Atractylodes lancea exhibited continuous-bead-like or nodular cylindrical shape, with occasional branches and multiple curvatures, measuring 3~5 ~ 10cm in length and 0.5~1 ~ 2cm in diameter. The surface was gray-brown or black-brown, with Root marks and tiny fibrous roots, and residual stem marks. Solid quality. The fracture surface is flat, yellow-white or gray-white, with most red-brown oil spots scattered, commonly known as "Cinnabar spots", with long exposure, most of which can precipitate white fine needle-like crystals. There is a strong specific aroma, taste slightly sweet and bitter. The shape is like a bead, solid, the skin is dark brown, the cross section is yellow-white, and the cinnabar point is better. 2. Atractylodes lancea exhibited nodular cylindrical shape, with branches or irregular mass, measuring 2~6 ~ 10cm in length and 1~1.5 ~ 3cm in diameter. The surface was black-brown, with round stem and root marks. The surface of the person who struck the skin was yellow-brown. The broken surface was fibrous, light yellow-white, with scattered yellow-brown oil spots. It is fragrant, but weak, with slightly bitter taste. A hypertrophic, firm, to remove the net hair, Smell fragrance is better. Physical and Chemical identification chemical characterization take 1g of powder, add 5ml of ether, shake and Leach for 15 minutes, and filter. Take 2ml of the filtrate and put it in an evaporation dish, add 1ml of 10% sulfuric acid solution containing 5% p-dimethylaminobenzaldehyde after the ether is evaporated, showing Rose Red, after baking at 100 ℃ for 5 minutes, Green color appeared (green color was not obvious after baking Atractylodes lancea oil). The Acetone Extract (10mg/2ml) was identified by spectrum, and the infrared spectrum of the sample was measured by potassium bromide tablet method. The sample had a sharp strong peak at 1 740cm-1, there was 1 peak of steamed bread at 1 650cm-1. thin layer chromatography ① 50-10% g of powder was taken, the volatile oil was extracted with a volatile oil extractor, a certain amount was absorbed, and diluted with ethyl acetate into solution for spotting. Adsorbent: 3g of silica gel (Qingdao, 180 mesh), 0.5% of sodium carboxymethylcellulose aqueous solution was added and ground, and then spread on a glass plate with a thickness of about 0.25, dried and baked at 100 ° C. For 1 hour. Develop with benzene-ethyl acetate-hexane (15: 15: 70) with a 20cm span. After spraying with a 10% sulfuric acid solution containing 5% of p-dimethylaminobenzaldehyde, it was baked at 100 ° C. For 5 minutes. Results: after spraying the chromogenic agent, atractylodes ketone showed red color immediately and then became purple after baking, the brown color of Makino alcohol and eucalyptol was in the same position (after spraying the color developing agent, the Atractylodes lancea oil turned blue gradually at the position corresponding to atractylodis). ② 0.5g of powder was taken, and 2ml of n-hexane was added, followed by ultrasonic treatment for 15 minutes, and the filtrate was used as a test solution. Another control medicinal materials of Atractylodes lancea were prepared with the same method as the control medicinal solution. 2~6 μl of each of the newly prepared two solutions, respectively, on the same silica gel G thin plate, with petroleum ether (60~90 ℃)-ethyl acetate (20: 1) develop with 10% sulfuric acid ethanol solution of 5% p-dimethylaminobenzaldehyde, and blow hot air until the spots are clear. The test article and the control article are spots of the same color at corresponding positions. And have the same stain green spot (Atractylodes). |
| pharmacology of traditional Chinese medicine | . It belongs to spleen and stomach Meridian.|
| determination of content | GC method (1) chromatographic condition detector: hydrogen flame detector; Column: 3mm × 2M, filler: 2.5% × E-60chromosorb WAW DMCS,80-100 mesh; Column temperature: 150 ℃; Injector temperature: 280 ℃; Nitrogen flow rate: 30ml/min. (2) preparation of reference solution precise weighing atractylodis, atractylodes ketone, total alcohol, β-eucalyptol each appropriate amount, and ether were made into a solution containing about 0.01mg per ml, as a control solution. (3) preparation of sample solution 100mg of sample powder (40 mesh) was accurately weighed, placed in a 10ml stopper test tube, 5.0ml of diethyl ether was added, ultrasonic extraction was carried out for 10min at room temperature, and allowed to stand at room temperature, the supernatant was used as the sample solution. (4) determination: 2 μl of each of the sample solution and the reference solution were accurately absorbed, and the sample was injected for determination. (5) chromatogram FIG. 2 is a gas chromatogram of Atractylodes lancea. Atractylodes rhizome ketone; 2.3. Β-eucalyptol; 4. Atractylodin (6) determination results FIG. 3 is the determination results of soluble components in ethanone of Atractylodes lancea (%) TLCS method (1) chromatographic conditions: silica gel GF254 plate; Developing solvent: petroleum ether-ethyl acetate (50:1); Color development: review under UV lamp. (2) preparation of reference solution: the appropriate amount of Atractylodes lancea reference was accurately weighed to prepare 1 mg/ml n-hexane solution. (3) preparation of sample solution: 10g of the powder of Atractylodes lancea decoction pieces was accurately weighed, extracted with n-hexane in a Soxhlet extractor for 5h, and adjusted to 50ml, as a sample solution. (4) determination: accurately measure 10 μl of the reference substance and the sample solution, and the intersection point is on the same thin layer plate, expand according to the above chromatographic conditions, take out, dry, scanning according to thin layer scanning method, λs = 336Nm, λr = 236nm; Reflective Sawtooth scanning; Slit 10mm; Sx = 3. The absorbance integral value of the measured sample and the reference product is calculated and obtained. (5) chromatogram FIG. 4 is a thin-layer chromatogram of Atractylodes lancea. Atractylodes lancea; 2. Atractylodin (6) determination results: 9 times, the average content was 3.95mg/g,RSD = 0.95%. |
| processing | (1) raw Atractylodes lancea: take the original medicinal material, remove impurities, wash, wet, cut thick and dry. (2) bran fried Atractylodes lancea: Take the bran and spread it into a hot pot, heat it over medium heat, add the Rhizoma atractylodis tablets when smoking, stir and stir until the surface is dark yellow, take it out, remove the Coke Bran by sieving and cool. 10kg of Bran was used for every 100kg of Atractylodes lancea tablets. (3) preparation of Atractylodes lancea: The net atractylodes was taken out, soaked in the water for a moment, and then taken out, and then dried with gentle fire. |
| Chemical properties | from Atractylodes lancea (Thunb.) DC. |
| Use | for content determination/identification/pharmacological experiments. Pharmacological Efficacy: hepatoprotective effect, anti-hypoxic effect, effect on the nervous system, hypoglycemic effect, anti-inflammatory and antitumor effect, antibacterial and antiviral effect, antiarrhythmic effect, effect on the digestive tract. |
Last Update：2024-04-09 15:16:42
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QQ: 2853786052
Wechat: 15671228036
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Product Name: Atractylodin Visit Supplier Webpage Request for quotationCAS: 55290-63-6
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Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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